High antioxidant levels are associated with a reduced risk of periodontitis

Periodontitis is an inflammatory disease that affects the supporting tissues of the teeth and is associated with an increased risk of stroke, type-2 diabetes, and heart disease. A new study reveals that increased serum antioxidant concentrations are associated with a reduced risk of periodontitis, even in people who have never smoked.

Periodontitis is an inflammatory condition of the tissue surrounding the teeth which has been linked with an increased risk of stroke, type-2 diabetes, and heart disease. A new report published in the Journal of Nutrition revealed that higher serum antioxidant levels are associated with a reduction in the risk of periodontitis.

The current research examined data from 11,480 participants in the Third National Health and Nutrition Examination Survey (NHANES III), for whom periodontal measurements and serum levels of several antioxidants had been recorded. These antioxidants included alpha-carotene, beta-carotene, selenium, lutein, beta-cryptoxanthin, vitamins A, C and E, and total antioxidant levels.

Mild periodentitis was found in 14% of the subjects and 5% had severe disease. Higher vitamin C and total antioxidant levels were associated with a lower incidence of periodontitis, especially with severe disease. Individuals whose vitamin C levels were in the top 20% of participants had a 39% lower risk of periodontitis than participants with the lowest intakes. For subjects who had never smoked, those with the highest intake of vitamin C experienced only half the risk of periodontitis compared to those with the lowest vitamin C levels.

Vitamin C has a role in collagen synthesis and maintenance of connective tissue, which may explain its benefit in protecting against periodontitis. In addition, it is known as a potent antioxidant that may also help reduce inflammation.

Journal of Nutrition Vol. 137, 657-664, March 2007.

Increased fiber intake protects against cardiovascular disease risk factors

Increasing dietary fiber intake to at least 25 grams per day from varied sources provides a significant protective effect against cardiovascular disease. Researchers presumed that fiber intakes of 30-35 grams per day would likely provide an even greater protective effect.

Increased dietary fiber intake is associated with reduced levels of a number of cardiovascular disease risk factors. The results of a study published in the American Journal of Clinical Nutrition add to a growing body of evidence linking higher dietary fiber intake with a lower risk of heart disease. Nearly 6,000 men and women were selected from participants in an ongoing trial designed to evaluate the effect of antioxidants on cancer and heart disease incidence over an eight year period.

The highest total of insoluble dietary fiber intakes were associated with reductions in the risks of overweight and elevated waist-to-hip ratio, blood pressure, cholesterol, triglycerides, and homocysteine. Fiber from cereals was associated with a lower body mass index, blood pressure, and homocysteine concentration; fiber from vegetables with a lower blood pressure and homocysteine concentration; and fiber from fruit with a lower waist-to-hip ratio and blood pressure. Fiber from dried fruit or nuts and seeds was associated with a lower body mass index, waist-to-hip ratio, and glucose concentrations.

The findings of this study illustrate the significance of increasing fiber intake from various dietary sources. The results also indicate that 25 grams total dietary fiber per day is the minimum intake required to attain a significant protective effect against cardiovascular disease, and that total dietary fiber intakes of 30-35 grams/day will likely provide an even greater protective effect.

American Journal of Clinical Nutrition, Vol. 82, No. 6, 1185-1194, December 2005

Calcium and vitamin D enhance heart health benefits of weight loss

Weight loss and reduced waist circumference are related to an improvement in heart health and factors related to metabolic syndrome. According to a new study, supplementing with calcium and vitamin D during weight loss enhances heart health benefits in women with typically low calcium intake.

Recent research has shown that overweight individuals with low calcium and dairy consumption are at increased risk of developing metabolic syndrome. The findings suggest that adequate calcium intake could create a healthier metabolic profile similar to a balanced diet and regular exercise.

In a new study, researchers investigated this issue by testing cardiovascular benefits of long-term calcium supplementation in women with usual low calcium intake. Healthy, overweight or obese women with a daily calcium intake of less than 800 mg/day were randomly assigned to 1 of 2 groups: the group consuming 2 tablets/day of a calcium + vitamin D supplement (600 mg elemental calcium and 200 IU vitamin D/tablet) or the group consuming placebo. Both groups completed a 15-week reduced calorie weight-loss program.

Significant decreases in LDL cholesterol levels, as well as the ratios of Total to LDL and LDL to HDL were seen the calcium +D group. These changes were independent of the changes due to fat loss and reduced waist circumference. A tendency for more beneficial changes in HDL cholesterol, triglycerides, and total cholesterol was also observed in the calcium +D group.

This was the first study to show that consumption of calcium +D during weight-loss enhances the beneficial effect of body weight loss on cardiovascular risk factors in overweight women with typically low calcium intake.

American Journal of Clinical Nutrition, Vol. 85, No. 1, 54-59, January 2007

Lifestyle improvements are as effective as medications in reducing diabetes risk

Lifestyle changes appear to be at least as effective as medications in delaying or preventing type 2 diabetes among adults with impaired glucose tolerance, and are associated with significantly fewer side effects according to a new report published in the British Medical Journal.

The increase in obesity and decrease in physical activity in Westernized societies are strongly linked with the increase in prevalence and incidence of type 2 diabetes. People with impaired glucose tolerance have an increased risk of developing type 2 diabetes, and many trials have focused on such individuals. Various treatment methods have been utilized in research, including pharmacological (medications), lifestyle and herbal remedies.

A recent meta-analysis published in the British Medical Journal consolidated the evidence from 17 clinical trials that studied the effects of lifestyle, drugs and other methods on men and women with impaired glucose tolerance. Results showed that intervention can reduce the risk of type 2 diabetes in high risk individuals, and lifestyle changes seem to be at least as effective as drug therapy. Compared to individuals who received standard advice only, the effect of lifestyle changes resulted in a 49 percent reduction in the risk of developing diabetes. Exercise alone or exercise combined with a healthier diet was more effective than diet alone. Oral diabetic medications were also effective in delaying or preventing diabetes, but were not as effective as lifestyle changes. Orlistat, an anti-obesity drug, was also effective in reducing risk when compared to control groups.

Although both medications and lifestyle changes were effective in reducing the risk of diabetes, diet and exercise were associated with considerably fewer adverse effects than those caused by pharmaceuticals, which were typically gastrointestinal effects and reduced liver function. Since it is fundamentally a lifestyle issue, the authors had concerns about the practice of treatment with a lifelong course of medication, especially since even minor adverse effects become more significant if a medication is to be taken for life. But they also noted that compliance is generally the key when it comes to lifestyle interventions, so strategies to improve compliance need to be enhanced and put into action.

BMJ. 2007 Jan 19; [Epub ahead of print]